Detection of cortical lesions in multiple sclerosis using FLAIR, DIR and ultra high field MPRAGE
نویسندگان
چکیده
E. C. Tallantyre, J. E. Dixon, M. J. Brookes, A. Al-Radaideh, P. S. Morgan, N. Evangelou, and P. G. Morris Clinical Neurology, Nottingham University, Nottingham, United Kingdom, Sir Peter Mansfield MR Centre, Nottingham University, Nottingham, United Kingdom, Radiology & Radiological Sciences, Medical University of South Carolina, Charleston, United States, Academic Radiology, Nottingham University, Nottingham, United Kingdom
منابع مشابه
3 Tesla and 7 Tesla MRI of multiple sclerosis cortical lesions.
Cortical lesions are prevalent in multiple sclerosis but are poorly detected using MRI. The double inversion recovery (DIR) sequence is increasingly used to explore the clinical relevance of cortical demyelination. Here we evaluate the agreement between imaging sequences at 3 Tesla (T) and 7T for the presence and appearance of individual multiple sclerosis cortical lesions. Eleven patients with...
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OBJECTIVE To assess the sensitivity and specificity of 3D double inversion recovery (DIR) MRI for detecting multiple sclerosis (MS) cortical lesions (CLs) using a direct postmortem MRI to histopathology comparison. METHODS Single-slab 3D DIR and 3D fluid-attenuated inversion recovery (FLAIR) images of 56 matched fresh brain samples from 14 patients with chronic MS were acquired at 1.5 T. The ...
متن کاملIncreased cortical grey matter lesion detection in multiple sclerosis with 7 Tesla MRI : a postmortem verification study 2 . 3 7 T postmortem MRI and histopathology study
The relevance of cortical grey matter pathology in multiple sclerosis has become increasingly recognised over the past decade. Unfortunately, a large part of cortical lesions remain undetected on MRI using standard field strength. In vivo studies have shown improved detection by using higher magnetic field strengths up to 7 T. So far, a systematic histopathological verification of ultrahigh-fie...
متن کاملDouble inversion recovery brain imaging at 3T: diagnostic value in the detection of multiple sclerosis lesions.
BACKGROUND AND PURPOSE To prospectively determine the sensitivity in the detection of multiple sclerosis (MS) lesions by using double inversion recovery (DIR), fluid-attenuated inversion recovery (FLAIR), and T2-weighted turbo spin-echo (T2 TSE) MR imaging at 3T. METHODS Seventeen patients presenting with a clinically isolated syndrome (CIS) suggestive of MS, 9 patients with definite MS, and ...
متن کاملMulticontrast MR imaging at 7T in multiple sclerosis: highest lesion detection in cortical gray matter with 3D-FLAIR.
BACKGROUND AND PURPOSE 7T MR imaging has led to improved detection and classification of cortical MS lesions, mainly based on T2*-weighted gradient-echo sequences. Depiction of cortical GM by using the recommended MS imaging protocol has not yet been investigated at 7T. We aimed to investigate prospectively which recommended sequence for clinical use has the highest value at 7T, in terms of GM ...
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